Mydekla is available has tablet form and belongs to class of antiviral medication.
Mydekla possess antiviral activity and will inhibits the NS5Adomain of hepatitis C virus (HCV)
Usually it is not regard as a monotherapy treatment but used with the combination of other antiviral drugs like Sofosbuvir and ribavirin.
During the treatment are exotic will increases in serum enzymes level, it has sufficiently suspected in case of clinically apparent hepatic injury like jaundice.


Mydekla an anti viral medication, used to treat hepatitis C virus from replicating in the body. It is also used to treat genotype III chronic hepatitis C virus (HCV) in adolescent without cirrhosis.
Mydekla not used separately, it should be combined with Sofosbuvir. Mydekla Tablet is used in combination form only, with other anti viral medications such as Sofosbuvir, interferon and ribavirin for the treatment of hepatitis C infection.


Mydekla with ribavirin contraindicated to pregnancy condition
Hypersensitivity reaction occur
Concurrent use of CYP3A inducers strong with Mydekla , contraindicated to the patients

Brand Name: Mydekla
Composition: Daclatasvir dihydrochloride tablets
Strength: 60mg
Dosage form: Tablet
Manufactured by: Mylan
Packing: 28 tablets in plastic container




Mydekla not used alone, it is combined with Sofosbuvir.
Genotype I:
Without cirrhosis and compensated cirrhosis: Mydekla with Sofosbuvir for 12 weeks
Decompensated cirrhosis: Mydekla with Sofosbuvir combined with ribavirin for 12 weeks.
Genotype III:
Without cirrhosis: Mydekla with Sofosbuvir for 12 weeks
Compensated or decompensated cirrhosis: Mydekla with Sofosbuvir combined with ribavirin for 12 weeks.

Dose modification of Mydekla:

Strong CYP3A inhibitors and certain Anti retroviral agents: Dosage of Mydekla is 30mg orally as single dose
Moderate CYP3A inducers and Nevirapine: dose should be 90mg orally
Strong CYP3A inducers: Mydekla is contraindicated.
OVERDOSAGE: Mydekla overdose has no particular antidote. Treatment will consist of supportive measures, involving monitoring of vitals and patient clinical status observation.


Mydekla is a direct acting anti viral agent which is used to cure chronic symptomatic HCV infection, with combination of Sofosbuvir .
Mydekla NS5A protein inhibitor
Sofosbuvir - direct acting nucleotide analogue inhibitor, NS5B polymerase inhibitor.
Both leading drug undergoes to inhibit polymerase enzyme which is responsible for viral replication.
Blocks the action of HCV NS5B polymerase leads to chain termination.
Ribavirin, it is a synthetic ribonucleic analogue which is incorporated into RNA blocking RNA synthesis. When ribavirin is used alone, it does not have anti viral property.

The peak serum concentration of Mydekla occurred within 2 hours.
Human plasma protein binding of Mydekla is approximately 99%. The volume of distribution is 47L.
CYP3A, it is substrate of Mydekla combined with CYP3A4 (CYP isoform) essential for metabolism.
The terminal half life period of Mydekla is around 12 to 15 hours.


→ HMG CoA reductase: increase the effect of concentration of these lipid lowering drugs
Mydekla is an inhibitor of P-glycoprotein transporter, organic anion transporting polypeptide and breast cancer resistance protein; taking Mydekla, may elevate exposure to these drugs, which prolong the therapeutic effect
→ Interaction with Proteases inhibitors will have high Mydekla effect of concentration .
→ Strong inducers of CYP3A causes decreased therapeutic effect of Mydekla
→ Strong CYP3A inhibitors: increase the effect of concentration of Mydekla
Mydekla combination with amiodarone and Sofosbuvir then use with caution because it will cause bradycardia
If patients while on treatment with Mydekla they have heart disease, hepatic impairment, hepatitis B reactivation occurs after discontinuation then care should be taken and give piror information to the doctor .


Pregnancy category is B while Mydekla using as alone treatment, safe to use during pregnancy but should get advice from medical practitioner.
During combination with other antiviral drug then pregnancy categories with ribavirin-X; causes severe ill effects like fetal harm even to death

LACTATION Breast feeding is safe during monotherapy but in combination with ribavirin breast feeding is not recommended.

Mydekla tablets containers are stored at 25oC to 77oF
Keep away from heat, moisture and heat.
Store the drug in its own container
Dispose the drug by asking advice from pharmacist.

If patient fail to take the dose of Mydekla tablet, must consult with physician and take the missed dose within the time.
Otherwise the missed dose should be skipped and follow the regular dosing schedule.
Do not take extra dose at same time.


Serious side effects Chest pain or discomfort, lightheadedness, dizziness, or fainting, slow or irregular heartbeat, unusual tiredness

More common Headache ,nausea
Less common :
Nervous system
Headache Dizziness, migraine, somnolence

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