DACTOVIN

Dactovin is available has tablet form and belongs to class of antiviral medication.
Dactovin possess antiviral activity and will inhibits the NS5Adomain of hepatitis C virus (HCV)
Usually it is not regard as a monotherapy treatment but used with the combination of other antiviral drugs like Sofosbuvir and ribavirin.
During the treatment are exotic will increases in serum enzymes level, it has sufficiently suspected in case of clinically apparent hepatic injury like jaundice.


INDICATIONS

Dactovin an anti viral medication, used to treat hepatitis C virus from replicating in the body. It is also used to treat genotype III chronic hepatitis C virus (HCV) in adolescent without cirrhosis.
Dactovin not used separately, it should be combined with Sofosbuvir. Dactovin Tablet is used in combination form only, with other anti viral medications such as Sofosbuvir, interferon and ribavirin for the treatment of hepatitis C infection.


CONTRAINDICATIONS

Dactovin with ribavirin contraindicated to pregnancy condition
Hypersensitivity reaction occur
Concurrent use of CYP3A inducers strong with Dactovin, contraindicated to the patients

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Brand Name: Dactovin
Composition: Daclatasvir dihydrochloride tablets
Strength: 60mg
Dosage form: Tablet
Manufactured by: Strides
Packing: 28 tablets in plastic container

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ABOUT DACTOVIN

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Dactovin not used alone, it is combined with Sofosbuvir,
Genotype I:
Without cirrhosis and compensated cirrhosis: Dactovin with Sofosbuvir for 12 weeks
Decompensated cirrhosis: Dactovin with Sofosbuvir combined with ribavirin for 12 weeks.
Genotype III:
Without cirrhosis: Dactovin with Sofosbuvir for 12 weeks
Compensated or decompensated cirrhosis: Dactovin with Sofosbuvir combined with ribavirin for 12 weeks.


Dose modification of Dactovin:

Strong CYP3A inhibitors and certain Anti retroviral agents: Dosage of Dactovin is 30mg orally as single dose
Moderate CYP3A inducers and Nevirapine: dose should be 90mg orally
Strong CYP3A inducers: Dactovin is contraindicated.
OVERDOSAGE: Dactovin overdose has no particular antidote. Treatment will consist of supportive measures, involving monitoring of vitals and patient clinical status observation.

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Dactovin is a direct acting anti viral agent which is used to cure chronic symptomatic HCV infection, with combination of Sofosbuvir .
Dactovin NS5A protein inhibitor
Sofosbuvir- direct acting nucleotide analogue inhibitor, NS5B polymerase inhibitor.
Both leading drug undergoes to inhibit polymerase enzyme which is responsible for viral replication.
Blocks the action of HCV NS5B polymerase leads to chain termination.
Ribavirin, it is a synthetic ribonucleic analogue which is incorporated into RNA blocking RNA synthesis. When ribavirin is used alone, it does not have anti viral property.


Absorption:
The peak serum concentration of Dactovin, occurred within 2 hours.
Distribution:
Human plasma protein binding of Dactovin is approximately 99%. The volume of distribution is 47L.
Metabolism:
CYP3A, it is substrate of Dactovin combined with CYP3A4 (CYP isoform) essential for metabolism.
Excretion:
The terminal half life period of Dactovin is around 12 to 15 hours.

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→ HMG CoA reductase: increase the effect of concentration of these lipid lowering drugs
Dactovin is an inhibitor of P-glycoprotein transporter, organic anion transporting polypeptide and breast cancer resistance protein; taking Dactovin, may elevate exposure to these drugs, which prolong the therapeutic effect
→ Interaction with Proteases inhibitors will have high Dactovin effect of concentration .
→ Strong inducers of CYP3A causes decreased therapeutic effect of Dactovin
→ Strong CYP3A inhibitors: increase the effect of concentration of Dactovin
PRECAUTIONS
Dactovin combination with amiodarone and Sofosbuvir then use with caution because it will cause bradycardia
Dactovin combination with amiodarone and Sofosbuvir then use with caution because it will cause bradycardia

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PREGNANCY
Pregnancy category is B while Dactovin using as alone treatment, safe to use during pregnancy but should get advice from medical practitioner.
During combination with other antiviral drug then pregnancy categories with ribavirin-X; causes severe ill effects like fetal harm even to death

LACTATION Breast feeding is safe during monotherapy but in combination with ribavirin breast feeding is not recommended.

STORAGE:
Dactovin tablets containers are stored at 25oC to 77oF
Keep away from heat, moisture and heat.
Store the drug in its own container
Dispose the drug by asking advice from pharmacist.

MISSED DOSE:
If patient fail to take the single dose of drug, must consult with physician and take the missed dose within the time.
Otherwise the missed dose should be skipped and follow the regular dosing schedule.
Do not take extra dose at same time.

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Serious side effects Chest pain or discomfort, lightheadedness, dizziness, or fainting, slow or irregular heartbeat, unusual tiredness

More common Headache ,nausea
Less common :
Diarrhea



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